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Literature summary extracted from

  • Reese, J.S.; Roth, J.C.; Gerson, S.L.
    Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance (2008), Stem Cells, 26, 675-681.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.63 N,N'-bis(2-chloroethyl)-N-nitrosourea BCNU Mus musculus

Application

EC Number Application Comment Organism
2.1.1.63 medicine the results suggest that expression of MGMT could enhance the capacity of bone marrow-derived cells to repopulate lung epithelium, and when used in combination with a gene of interest, MGMT could have therapeutic applications Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.63 P140K mutant confers resistance to N,N'-bis(2-chloroethyl)-N-nitrosourea and O(6)-benzylguanine Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.63 O(6)-benzylguanine BG Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + [protein]-L-cysteine Mus musculus
-
 DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 bone marrow
-
 Mus musculus
-
2.1.1.63 lung epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
-
 Mus musculus DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 AGT
-
 Mus musculus
2.1.1.63 methylguanine DNA methyltransferase
-
 Mus musculus
2.1.1.63 MGMT
-
 Mus musculus
2.1.1.63 O6-alkylguanine-DNA alkyltransferase
-
 Mus musculus